Hydrophobic-Polar model is a simplified representation of Protein Structure Prediction (PSP) problem. However, even with the HP model, the PSP problem remains NP-complete. This work proposes a systematic and problem specific design for operators of the evolutionary program which hybrids with local search hill climbing, to efficiently explore the search space of PSP and thereby obtain an optimum conformation. The proposed algorithm achieves this by incorporating the following novel features: (i) new initialization method which generates only valid individuals with (rather than random) better fitness values; (ii) use of probability-based selection operators that limit the local convergence; (iii) use of secondary structure based mutation oper...
Protein Structure Prediction (PSP) from the primary amino acid sequence, even using a simplified Hyd...
Ab initio protein structure prediction is an important prob-lem for which several algorithms have be...
Predicting the minimum energy protein structure from its amino acid sequence, even under the rather ...
Protein is a sequence of amino acids bounded into a linear chain that adopts a specific folded three...
In-vitro methods for protein structure determination are time-consuming, cost-intensive, and failure...
Technical reportThe prediction of a minimum energy protein structure from its amino acid sequence re...
ABSTRACT This paper presents a new Genetic Algorithm for Protein Structure Prediction problem in bot...
Abstract. The hydrophobic-polar (HP) model for protein structure pre-diction abstracts the fact that...
Evolutionary algorithms (EAs) have been shown to be competent at solving complex, multimodal optimis...
Proteins are cellular macromolecules made up of linear chains of amino acids that adopt a unique thr...
The primary structure of proteins consists of a linear chain of amino acids that can vary in length....
The prediction of a minimum energy protein structure from its amino acid sequence represents an impo...
Abstract—Protein structure prediction is one of the most challenging problems in computational biolo...
Protein Structure Prediction (PSP) problem is to determine the three-dimensional structure of a prot...
Protein structure prediction is considered as one of the most challenging and computationally intrac...
Protein Structure Prediction (PSP) from the primary amino acid sequence, even using a simplified Hyd...
Ab initio protein structure prediction is an important prob-lem for which several algorithms have be...
Predicting the minimum energy protein structure from its amino acid sequence, even under the rather ...
Protein is a sequence of amino acids bounded into a linear chain that adopts a specific folded three...
In-vitro methods for protein structure determination are time-consuming, cost-intensive, and failure...
Technical reportThe prediction of a minimum energy protein structure from its amino acid sequence re...
ABSTRACT This paper presents a new Genetic Algorithm for Protein Structure Prediction problem in bot...
Abstract. The hydrophobic-polar (HP) model for protein structure pre-diction abstracts the fact that...
Evolutionary algorithms (EAs) have been shown to be competent at solving complex, multimodal optimis...
Proteins are cellular macromolecules made up of linear chains of amino acids that adopt a unique thr...
The primary structure of proteins consists of a linear chain of amino acids that can vary in length....
The prediction of a minimum energy protein structure from its amino acid sequence represents an impo...
Abstract—Protein structure prediction is one of the most challenging problems in computational biolo...
Protein Structure Prediction (PSP) problem is to determine the three-dimensional structure of a prot...
Protein structure prediction is considered as one of the most challenging and computationally intrac...
Protein Structure Prediction (PSP) from the primary amino acid sequence, even using a simplified Hyd...
Ab initio protein structure prediction is an important prob-lem for which several algorithms have be...
Predicting the minimum energy protein structure from its amino acid sequence, even under the rather ...