STUDY OF THE EXCIPIENTS INFLUENCE ON PHARMACO-TECHNOLOGICAL PROPERTIES OF FLAMMULINA VELUTIPES BIOMASS DRY POWDER TABLETS

The aim of the work. Studying the impact of four groups of excipients (fillers, disintegrants, lubricants and glidants, binders) on the pharmaco-technological properties of Flammulina velutipes biomass dry powder tablets. Materials and Methods. Research of the impact of excipients on such parameters as surface quality, uniformity of weight, resistance to crushing, friability and disintegration of tablets was carried out in accordance to the requirements of State Pharmacopoeia of Ukraine 2nd edition using the method of mathematical experiment planning. Results and Discussion. Сonclusions about the impact of excipients on F. velutipes biomass dry powder tablets quality indicators were made based on comparisons of multiple levels of studied factors. When using any of representatives of the groups of excipients we obtained similar results of impact on tablet weight uniformity. Satisfactory results of tablet friability were obtained in 13 series of experiments, 5 of them had an average of less than 0.5 %. Compressed F. velutipes biomass dry powder tablets had different strength values, only in 9 series of experiments the index was above 50 N. 7 unsatisfactory series of the preparation were found during the study of the effect of excipients on the disintegration of tablets. Conclusions. The influence of four groups of the excipients on such pharmaco-technological properties of Flammulina velutipes biomass dry powder tablets as surface quality, uniformity of weight, resistance to crushing, friability and disintegration was found. Optimal representatives of the studied groups of excipients (powdered sugar, kaolin, stearic acid, 2 % starch paste) were selected for the production of Flammulina velutipes biomass dry powder tablets by the wet granulation method