SYNTHESIS AND ANTIBACTERIAL PROPERTIES OF 4-AMINOPHENYLSULFONAMIDE IMMOBILIZED ON THE POLYMERIC CARRIER

The aim of the study. Today the immobilization of drugs to the polymeric carriers is increasingly important, due to the requirements to reduce the toxicity and prolongation of action of drugs. It is known the immobilization of the Sulfonamides on the Stiromali, methacrylate polymer matrices, wherein the pharmacologically active sulfanilamide easily remove from the polymer upon the application, by the acid hydrolysis. At the same time it is noted that immobilized sulfonamides derived from aminomethylated Styrene-divinylbenzene copolymer, although hydrolytic stability, maintain the antibacterial properties. In order to expand the examples of covalent immobilization of sulfonamides we synthesized 4-aminophenylsulfonamide on pellet and brous forms of styrene and divinylbenzene with SO2 as a bridging group. Materials and Methods. As a raw materials, we used the pellet macroporous sulfonated Styrene-divinylbenzene copolymer and copolymers Polypropylene and Styrene. Sulfochlorination of these copolymers the polymeric sulfonyl chlorides were obtained. This compounds were used in the reaction with 4-aminophenilsulfonamidom. Antibacterial properties of the material were studied by determining the growth inhibition zones of test E. coli K12 microorganism in a nutrient medium. Results and Discussion. The structure of synthesized immobilized 4-aminophenylsulfonamide proven by IR spectroscopy. It is shown that such materials exhibit a relatively pronounced antibacterial properties test culture of microorganisms E. coli K-12, in spite of their resistance to hydrolysis. Сonclusions. It is suggested that the hydrolysis of the materials takes place at a specic enzymatic catalysis in the medium with the release of 4-aminophenylsulfonamide