An emerging novel goose astrovirus associated with gosling gout disease, China
- Xinyu Zhang
- Dan Ren
- Tuofan Li
- Huayan Zhou
- Xiaoyu Liu
- Xiaobo Wang
- Hao Lu
- Wei Gao
- Yajuan Wang
- Xiaoyan Zou
- Huaichang Sun
- Jianqiang Ye
DOIAbstract
Abstract Since the first isolation from human, astroviruses have been detected in many species. Wide host range and occasional cross-transmission of astrovirus pose a risk for zoonotic infection. Here, novel astroviruses were identified from goslings with recent epidemic gout disease in China. A virus, designated as GD, was efficiently isolated from a diseased gosling using LMH cells. Genome of GD amplified using 5′ and 3′ RACE was 7183nt in full length. Sequence analysis revealed the genome of GD was <60.8% homology with others deposited in Genbank. Moreover, GD could be neutralized by goose convalescent sera, and the gout associated symptom in goslings could be reproduced by GD infection. Our data demonstrated the goose astrovirus could b...
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