α-Synuclein (α-syn) is a major component of Lewy bodies found in synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Under the pathological conditions, α-syn tends to generate a diverse form of aggregates showing toxicity to neuronal cells and able to transmit across cells. However, mechanisms by which α-syn aggregates affect cytotoxicity in neurons have not been fully elucidated. Here we report that α-syn aggregates preferentially sequester specific synaptic proteins such as vesicle-associated membrane protein 2 (VAMP2) and synaptosomal-associated protein 25 (SNAP25) through direct binding which is resistant to SDS. The sequestration effect of α-syn aggregates was shown in a cell-free system, cultured ...
Cytoplasmic alpha-synuclein (α-syn) aggregates, including Lewy bodies (LBs), are pathological hallma...
α-synuclein (αSyn) is a protein known to form intracellular aggregates during the manifestation of P...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
<div><p>α-Synuclein (α-syn) is a major component of Lewy bodies found in synucleinopathies including...
Background The pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is assoc...
α-Synuclein (α-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene triplic...
<div><p>α-synuclein (α-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene...
Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), and Dementia...
a-synuclein (a-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene triplic...
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of d...
Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesi...
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of d...
Growing evidence indicates that the pathological alpha-synuclein (a-syn) aggregation in Parkinson's ...
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and misfolded α-...
alpha-synuclein (alpha-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene...
Cytoplasmic alpha-synuclein (α-syn) aggregates, including Lewy bodies (LBs), are pathological hallma...
α-synuclein (αSyn) is a protein known to form intracellular aggregates during the manifestation of P...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
<div><p>α-Synuclein (α-syn) is a major component of Lewy bodies found in synucleinopathies including...
Background The pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is assoc...
α-Synuclein (α-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene triplic...
<div><p>α-synuclein (α-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene...
Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), and Dementia...
a-synuclein (a-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene triplic...
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of d...
Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesi...
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of d...
Growing evidence indicates that the pathological alpha-synuclein (a-syn) aggregation in Parkinson's ...
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and misfolded α-...
alpha-synuclein (alpha-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene...
Cytoplasmic alpha-synuclein (α-syn) aggregates, including Lewy bodies (LBs), are pathological hallma...
α-synuclein (αSyn) is a protein known to form intracellular aggregates during the manifestation of P...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...