QUANTITATIVE MORPHOLOGICAL VALUE OF AGE PECULIARITIES OF TESTIS ARTERIES REMODELLING IN EXPERIMENTAL ANIMALS

In pathogenesis damage of the testis an important role belongs to blood-vessels bed especially its arteries. It is necessary to indicate that quantitative morphological changes of age peculiarities of remodelling of testis arteries is not fully studied. The aim of the study – quantitative morphological investigation of age peculiarities of remodeling of testis arteries in experimental animals. Materials and Methods. By complex morphological methods we studied middle (external diameter 51–125 mkm) and small (external diameters 26–50 mkm) arteries of testis in 17 white rats which were divided into 2 groups: the first group – nine 8-months rats (young animals); the second group – eight 24-months rats (old animals). Euthanasia of animals was performed by bloodletting in terms of thiopental anesthesia. By morphometrical methods on histological preparations we determined external and internal diameters arteries of testis, thickness of media, index Vogenvorta (relations area of vessel to area its aperture), height of endotheliocytes, diameter its nucleus, nucleo-cytoplasmatical relations in this cells, comparatively volume damaging endotheliocytes. Processing of quantitative data produced by the method of variation statistics. Results and Discussion. Analysis of the results revealed that with age quantitative morphological characteristics of small calibre arteries of testis is more pronounced. It was found out that with age, the outer diameter of small arteries increased by 3.3 %, the thickness of the media – by 11.3 %, the Vohenvort index – 41.1 %, the internal diameter of blood vessels decreased by 11.0 %. The relative amount of damaged endothelial cells in arteries of small calibre testes in animals older increased by 21.9 %, which most researchers associated with the growth of age apoptosis. Nuclear-cytoplasmic ratio in the endothelial cells of arteries of medium and small sizes did not change with age, indicating the structural stability of cellular homeostasis. Age wall thickening studied vascular narrowing of the lumen, the growth index Vohenvorta indicate a reduction of capacity and deterioration of blood supply to the studied organ. Conclusions. The age peculiarities of remodelling of testis arteries in laboratory white rats have been studied by means of quantitative morphological methods. It has been established that in testis increase arterial wall, space contraction, blood supply wоrsening of organ. Small-sized arteries got more expressed structural rearrangement