Morphological changes of aortic subendothelial layer and internal elastic membrane in modeling of chronic adrenergic and cholinergic stress

The article presents the results of a study of the aortic wall (subendothelial and the internal elastic membrane thickness) in simulation with different autonomic reaction to chronic stress. Chronic experiment was conducted on Wistar rats. Adrenergic stress was simulated by a two-week intraperitoneal administration of epinephrine, cholinergic stress - by neostigmine, mixed stress - by simultaneous administration of adrenaline and neostigmine. Adrenergic stress had no significant effect on the thickness of subendothelium, whereas cholinergic and mixed stresses were accompanied by a significant thickening of the subendothelium. The results obtained suggest that stress with predominant parasympathetic activation has a greater effect on the aortic subendothelium. Subendothelium alteration may lead to the development of fibrosis, arteriosclerosis, disturbance of blood rheology