Chronic kidney disease in the global adult HIV-infected population: A systematic review and meta-analysis.
- Udeme E Ekrikpo
- Andre P Kengne
- Aminu K Bello
- Emmanuel E Effa
- Jean Jacques Noubiap
- Babatunde L Salako
- Brian L Rayner
- Giuseppe Remuzzi
- Ikechi G Okpechi
DOIAbstract
The widespread use of antiretroviral therapies (ART) has increased life expectancy in HIV patients, predisposing them to chronic non-communicable diseases including Chronic Kidney Disease (CKD). We performed a systematic review and meta-analysis (PROSPERO registration number CRD42016036246) to determine the global and regional prevalence of CKD in HIV patients.We searched PubMed, Web of Science, EBSCO and AJOL for articles published between January 1982 and May 2016. CKD was defined as estimated glomerular filtration rate (eGFR) <60ml/min using the MDRD, Cockcroft-Gault or CKD-EPI equations. Random effects model was used to combine prevalence estimates from across studies after variance stabilization via Freeman-Tukey transformation.Sixty-o...
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