Mechanism of action of curcumin in treatment of pancreatic cancer

Curcumin is a polyphenol extracted from the rhizome of Rhizoma Curcumae Longae with anti-inflammatory, antioxidant, and antitumor effects. It can also increase the sensitivity to chemoradiotherapy and protect hepatic and renal function. It is involved in the regulation of various signaling pathways and the expression of oncogenes and thus may become a potential anti-tumor drug for pancreatic cancer. This article reviews the mechanism of action of curcumin in inhibiting the proliferation and inducing the apoptosis of pancreatic cancer cells and inhibiting the signaling pathways involved in pancreatic cancer