The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children
- Edith Cardenas-Vargas
- Jairo A. Nava
- Idalia Garza-Veloz
- Mayra C. Torres-Castañeda
- Carlos E. Galván-Tejada
- Miguel A. Cid-Baez
- Rosa E. Castañeda-Arteaga
- Yolanda Ortiz-Castro
- Perla M. Trejo-Ortiz
- Roxana Araujo-Espino
- Fabiana E. Mollinedo-Montaño
- Jose R. Muñoz-Torres
- Margarita L. Martinez-Fierro
DOIAbstract
Obesity is considered the main risk factor associated with the development of insulin resistance (IR). The aim of this study was to evaluate the influence of obesity on puberty onset and IR in Mexican children. A total of 378 children (189 boys and 189 girls) aged 8–14 years participated in the study. IR was estimated using the homeostasis model assessment for IR (HOMA-IR). The mean fasting glucose (FG) and basal insulin levels were 82 mg/dl and 11.0 μIU/ml in boys and 77.3 mg/dl and 12.3 μIU/ml in girls (P<0.05). Subjects with obesity at Tanner stages II–V showed increased FG levels (P<0.05). In boys with obesity, there was a decrease in HOMA-IR in Tanner stage IV and differences in age between boys with normal weight and those with obesit...
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