Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides

In this work, 15 different coumarin hydrazides were successfully synthesized and screened for their antioxidant and antilipase activities. To do this, firstly, salicylaldehyde derivatives and 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's Acid) were reacted in ethanol in the presence of catalytic amount of pyridine to obtain coumarin-3-carboxylic acid derivatives (1a-e). Then, these compounds were treated with benzotriazole in dichloromethane by using thionyl chloride to synthesized benzotriazole derivatives (2a-e). Then, compounds 2a-e were reacted with three commercial hydrazides (nicotinic hydrazide, benzhydrazide and phenylacetichydrazide) in ethanol by using microwave irradiation and conventional heating procedures to obtain final products (3-5a-e). Finally, these compounds were tested for their anti-oxidant and anti-pancreatic lipase activities. The structure of newly synthesized compounds was identified by 1H NMR, 13C NMR and elemental analysis data