ROS are frequently associated with deleterious effects caused by oxidative stress. Despite the harmful effects of non-specific oxidation, ROS also function as signal transduction molecules that regulate various biological processes, including stem cell proliferation and differentiation. Here we show that mitochondrial ROS level determines cell fate during differentiation of the pluripotent stem cell line P19. As stem cells in general, P19 cells are characterized by a low respiration activity, accompanied by a low level of ROS formation. Nevertheless, we found that P19 cells contain fully assembled mitochondrial electron transport chain supercomplexes (respirasomes), suggesting that low respiration activity may serve as a protective mechanis...
Given the considerable interest in using stem cells for modeling and treating disease, it is essenti...
Oxidative phosphorylation (OXPHOS), the intracellular process that generates the majority of the ATP...
International audienceAbstract Tissue stem cells and germ line or embryonic stem cells were shown to...
ROS are frequently associated with deleterious effects caused by oxidative stress. Despite the harmf...
Mitochondria are essential for the viability of mammalian cells and provide a compartment for specif...
Mitochondrial dynamics refers to a series of constant division and fusion cycles that form interconn...
Essential changes in cell metabolism and redox signaling occur during the reprogramming of somatic c...
Key Words. Stem cells • Reactive oxygen species • Cardiomyocyte • Mitochondria • Glucose Accumulatin...
SummaryAdipocyte differentiation is characterized by an increase in mitochondrial metabolism. Howeve...
AbstractMitochondrial energy production is involved in various cellular processes. Here we show that...
SummarymtDNA mutagenesis in somatic stem cells leads to their dysfunction and to progeria in mouse. ...
<div><p>Human mesenchymal stem cells (MSCs) are adult multipotent stem cells which can be isolated f...
mtDNA mutagenesis in somatic stem cells leads to their dysfunction and to progeria in mouse. The mec...
Pluripotent stem cells (PSCs) hold great potential both in studies on developmental biology and clin...
The 18-kDa translocator protein (TSPO) is a key mitochondrial target by which different TSPO ligands...
Given the considerable interest in using stem cells for modeling and treating disease, it is essenti...
Oxidative phosphorylation (OXPHOS), the intracellular process that generates the majority of the ATP...
International audienceAbstract Tissue stem cells and germ line or embryonic stem cells were shown to...
ROS are frequently associated with deleterious effects caused by oxidative stress. Despite the harmf...
Mitochondria are essential for the viability of mammalian cells and provide a compartment for specif...
Mitochondrial dynamics refers to a series of constant division and fusion cycles that form interconn...
Essential changes in cell metabolism and redox signaling occur during the reprogramming of somatic c...
Key Words. Stem cells • Reactive oxygen species • Cardiomyocyte • Mitochondria • Glucose Accumulatin...
SummaryAdipocyte differentiation is characterized by an increase in mitochondrial metabolism. Howeve...
AbstractMitochondrial energy production is involved in various cellular processes. Here we show that...
SummarymtDNA mutagenesis in somatic stem cells leads to their dysfunction and to progeria in mouse. ...
<div><p>Human mesenchymal stem cells (MSCs) are adult multipotent stem cells which can be isolated f...
mtDNA mutagenesis in somatic stem cells leads to their dysfunction and to progeria in mouse. The mec...
Pluripotent stem cells (PSCs) hold great potential both in studies on developmental biology and clin...
The 18-kDa translocator protein (TSPO) is a key mitochondrial target by which different TSPO ligands...
Given the considerable interest in using stem cells for modeling and treating disease, it is essenti...
Oxidative phosphorylation (OXPHOS), the intracellular process that generates the majority of the ATP...
International audienceAbstract Tissue stem cells and germ line or embryonic stem cells were shown to...