Identification and profiling of microRNA between back and belly Skin in Rex rabbits (Oryctolagus cuniculus)

Bohao Zhao
Yang Chen
Lin Mu
Shuaishuai Hu
Xinsheng Wu

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Publication date

June 2018

DOI

10.4995/wrs.2018.7058

Publisher

Universitat Politecnica de Valencia

Journal

World Rabbit Science

Abstract

Skin is an important trait for Rex rabbits and skin development is influenced by many processes, including hair follicle cycling, keratinocyte differentiation and formation of coat colour and skin morphogenesis. We identified differentially expressed microRNAs (miRNAs) between the back and belly skin in Rex rabbits. In total, 211 miRNAs (90 upregulated miRNAs and 121 downregulated miRNAs) were identified with a |log2 (fold change)|>1 and P-value<0.05. Using target gene prediction for the miRNAs, differentially expressed predicted target genes were identified and the functional enrichment and signalling pathways of these target genes were processed to reveal their biological functions. A number of differentially expressed miRNAs were found t...