Portal vein thrombosis in liver cirrhosis: incidence, management, and outcome

Shunichiro Fujiyama
Satoshi Saitoh
Yusuke Kawamura
Hitomi Sezaki
Tetsuya Hosaka
Norio Akuta
Masahiro Kobayashi
Yoshiyuki Suzuki
Fumitaka Suzuki
Yasuji Arase
Kenji Ikeda
Hiromitsu Kumada

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Publication date

October 2017

DOI

10.1186/s12876-017-0668-8

Publisher

Springer Science and Business Media LLC

Journal

BMC Gastroenterology

Abstract

Abstract Background Portal vein thrombosis (PVT) is a serious complication in liver cirrhosis with portal hypertension. We examined the treatment, recurrence and prognosis of PVT in cirrhotic patients. Methods The study subjects were all 90 cirrhotic patients with PVT treated with danaparoid sodium (DS) at our department between July 2007 and September 2016. The mean age was 68 years and mean Child-Pugh score was 7. All patients received 2500 U/day of DS for 2 weeks, and repeated in those who developed PVT recurrence after the initial therapy. Results Complete response was noted in 49% (n = 44), partial response (shrinkage ≥70%) in 33% (n = 30), and no change (shrinkage <70%) in 18% (n = 16) of the patients after the initial course of treat...