The aim of this paper is to provide some sketchy remarks on the post-empiricist phenomenon in philosophy of science, taking into account the themes of the relationships between language on the one side and reality on the other, and the parallel problem of the alleged elimination of metaphysics. Unlike the logical empiricists, Popper believes that a clear separation between (i) analytic and synthetic sentences, and (ii) between theory and observation, is an impossible task. According to his view, theory and observation are intimately linked to each other, and no pure observation is ever possible. A position very similar to Popper’s was endorsed by the American pragmatists in the last two centuries with Charles S. Peirce, William James and Jo...