TOPICAL TREATMENT OF CONTACT NICKEL DERMATITIS: THE POTENTIAL OF NANO-ENCAPSULATED SUPEROXIDE DISMUTASE

Contact dermatitis is one of the most common disorders today, which could be caused by different irritants, including nickel and its salts. Oxidative and nitrooxidative stress has been linked to a myriad of pathologies, such as skin diseases and contact dermatitis particularly. The aim of the study – an investigation of the efficacy of free and nano-encapsulated PEG ylated superoxide dismutase (SOD) in contact nickel dermatitis. Materials and Methods. Experiment was carried out on 40 white inbred rats, which were divided into 4 groups. 1st group – intact rats; 2nd – rats with contact nickel dermatitis (CD); 3rd – rats which got free form of SOD (CD + SOD); 4th – group which got nanocapsulated SOD (CD + nano- SOD ). Visual scale and thickness of skin fold were used for estimation of visible changes, also the intensity of oxidative and nitrooxidative stress was studied. Results and Discussion. Application of 5 % nickel sulfate caused prominent damage to skin and rising of oxidative and nitrooxidative stress with increased levels of lipoperoxidation products and simultaneous suppression of antioxidant defense indices. Topical administration of the free form of SOD decreases the signs of CD for visual scale and for significant suppression of lipid peroxidation processes with activation of endogenic antioxidant system’s indices. But nano-encapsulated form of SOD has prominently better consequences for damaged skin in comparison to CD-group and those rats, which got free-form of medicine for correction. Such significant difference was observed regarding the indices of lipid peroxidation processes and endogenic antioxidant system in blood serum and liver tissues. Conclusions. The results of our study showed the prospects for further study and clinical implementation of nano-encapsulated SOD for topical treatment of contact dermatitis