THE STATE OF MUCOSAL IMMUNITY AND MICROBIOCENOSIS OF THE GENITOURINARY TRACT IN PATIENTS WITH CHRONIC RECURRENT PYELONEPHRITIS

The aim - to examine the state of mucosal immunity and microbiocenosis of the genitourinary tract in patients with chronic pyelonephritis (PN) and determine their significance as risk factors of recurrences. Material and methods. In this research some 36 women mucosal immunity with recurrent PN had been investigated. Its peculiarities with the patients with recurrent PN (n=22) in comparison with relatively-healthy donors (n=12) as well as in comparison with sporadic disease (n=14). Some 16 females were investigated of biocenosis of vagina by the PLR real-time method. The material of the research was urine as well as scrapes of urethra and the cervical channel. The results of the research. The analysis of the quantity of microflora of vagina has indicated decreasing of Lactobacillus spp. In majority – 12 (75%) of the patients. During the investigations of hypostatis liquid of vagina the patients with PN, decreasing of intensity of phagocytosis of neutrophiles and macrophagus was indicated (р<0.001 and р=0.004, respectively), as well as increasing of phagocytosis activity of monocytes/macrofagus (р=0.01). The indicator of activation of neutrophiles as well as concentration Ig M surely high in the patients with S. faecalis in vagina (U=9.0; р=0,03 and ρ=0.64; р=0.007 respectively). The levels of lysozyme and lactoferrin in the urine of patients with pyelonephritis were significantly higher than those of conventionally healthy women (11.5 (1.7-27.1) vs 0.9 (0-1.2) ng/ml; р