The serotonergic and immunological hypothesis of depression proposes that certain types of excessive stress distort the relationship between the activities of the innate immune and central nervous systems, so that the stress caused by an infection, or excessive psychological stress, activate toll-like receptors such as the TLR-4, the transcription factor NF-kB, the inflammasome NLRP3, as well as the secretion of interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and other factors of the innate immune response, causing first, the general symptoms of the disease which appear with any infection, but also those characteristic of depressive illness such as dysphoria and anhedonia. The evidence indicates that, if the stimulus persists or recurs wit...
AbstractThe inflammation theory of depression, proposed over 20years ago, was influenced by early st...
Depression is an affective, physiologic, cognitive and behavioral disorder that affects regular beha...
It has become clear that the inflammatory immune system is altered during the course of clinical dep...
The serotonergic and immunological hypothesis of depression proposes that certain types of excessive...
The brain is no longer considered an immunoprivileged organ which is completely separated from the c...
La modulación del sistema inmunológico por el Sistema Nervioso Central (SNC) está mediada por una re...
Depression is the most frequent mental disorder worldwide whose pathology is complex due to the psyc...
Stressful events have been implicated in the provocation of depressive illness. Inasmuch as immunolo...
High levels of several proinflammatory components of the immune system, such as interleukin-6, C-rea...
peer reviewedComplex diseases are chronic diseases where the interrelations between genetic predispo...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Li...
INTRODUCTION. Sickness behavior is a highly organized adaptive strategy elicited by inflammation to ...
Proinflammatory cytokines play a role in major depressive disorder. A core symptom of major depressi...
La psiconeuroinmunología (PNI) se define como el estudio de las relaciones entre el sistema nervioso...
AbstractThe inflammation theory of depression, proposed over 20years ago, was influenced by early st...
Depression is an affective, physiologic, cognitive and behavioral disorder that affects regular beha...
It has become clear that the inflammatory immune system is altered during the course of clinical dep...
The serotonergic and immunological hypothesis of depression proposes that certain types of excessive...
The brain is no longer considered an immunoprivileged organ which is completely separated from the c...
La modulación del sistema inmunológico por el Sistema Nervioso Central (SNC) está mediada por una re...
Depression is the most frequent mental disorder worldwide whose pathology is complex due to the psyc...
Stressful events have been implicated in the provocation of depressive illness. Inasmuch as immunolo...
High levels of several proinflammatory components of the immune system, such as interleukin-6, C-rea...
peer reviewedComplex diseases are chronic diseases where the interrelations between genetic predispo...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Li...
INTRODUCTION. Sickness behavior is a highly organized adaptive strategy elicited by inflammation to ...
Proinflammatory cytokines play a role in major depressive disorder. A core symptom of major depressi...
La psiconeuroinmunología (PNI) se define como el estudio de las relaciones entre el sistema nervioso...
AbstractThe inflammation theory of depression, proposed over 20years ago, was influenced by early st...
Depression is an affective, physiologic, cognitive and behavioral disorder that affects regular beha...
It has become clear that the inflammatory immune system is altered during the course of clinical dep...