The anticipated biological and clinical utility of biomarkers has attracted significant interest recently. Aging and early cancer detection represent areas active in the search for predictive and prognostic biomarkers. While applications differ, overlapping biological features, analytical technologies and specific biomarker analytes bear comparison. Mitochondrial DNA (mtDNA) as a biomarker in both biological models has been evaluated. However, it remains unclear whether mtDNA changes in aging and cancer represent biological relationships that are causal, incidental, or a combination of both. This article focuses on evaluation of mtDNA-based biomarkers, emerging strategies for quantitating mtDNA admixtures, and how current understanding of m...
BackgroundMitochondrial DNA (mtDNA) deletion mutations lead to electron transport chain-deficient ce...
Circulating mitochondrial DNA (MtDNA) is a potential non-invasive biomarker of cellular mitochondria...
Accumulation of mitochondrial DNA (mtDNA) mutations leads to alterations of mitochondrial biogenesis...
The anticipated biological and clinical utility of biomarkers has attracted significant interest rec...
Background and aims: Individuals of the same species may have large variations in their ageing rates...
The last 30 years of research greatly contributed to shed light on the role of mitochondrial DNA (mt...
Abstract Background The accumulation of mitochondrial DNA (mtDNA) mutations, and the reduction of mt...
Changes in mitochondrial DNA (mtDNA) content is a useful clinical biomarker for various diseases, ho...
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and levels of mtDN...
Remarkable progress has been made in the last decade in new methods for biologic measurements using ...
[[abstract]]Background: Mitochondrial dysfunction is associated with various aging diseases. The cop...
Background: Telomeres (TL) shorten with age and in response to cellular stress or adverse health con...
A. Overrepresented nucleotides in tri- (left) or pentanucleotide (right) motifs flanking CG to TA tr...
Recent expansion of our knowledge on epigenetic changes strongly suggests that not only nuclear DN...
Mitochondrial DNA copy number (mtDNA-CN), a measure of the number of mitochondrial genomes per cell,...
BackgroundMitochondrial DNA (mtDNA) deletion mutations lead to electron transport chain-deficient ce...
Circulating mitochondrial DNA (MtDNA) is a potential non-invasive biomarker of cellular mitochondria...
Accumulation of mitochondrial DNA (mtDNA) mutations leads to alterations of mitochondrial biogenesis...
The anticipated biological and clinical utility of biomarkers has attracted significant interest rec...
Background and aims: Individuals of the same species may have large variations in their ageing rates...
The last 30 years of research greatly contributed to shed light on the role of mitochondrial DNA (mt...
Abstract Background The accumulation of mitochondrial DNA (mtDNA) mutations, and the reduction of mt...
Changes in mitochondrial DNA (mtDNA) content is a useful clinical biomarker for various diseases, ho...
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and levels of mtDN...
Remarkable progress has been made in the last decade in new methods for biologic measurements using ...
[[abstract]]Background: Mitochondrial dysfunction is associated with various aging diseases. The cop...
Background: Telomeres (TL) shorten with age and in response to cellular stress or adverse health con...
A. Overrepresented nucleotides in tri- (left) or pentanucleotide (right) motifs flanking CG to TA tr...
Recent expansion of our knowledge on epigenetic changes strongly suggests that not only nuclear DN...
Mitochondrial DNA copy number (mtDNA-CN), a measure of the number of mitochondrial genomes per cell,...
BackgroundMitochondrial DNA (mtDNA) deletion mutations lead to electron transport chain-deficient ce...
Circulating mitochondrial DNA (MtDNA) is a potential non-invasive biomarker of cellular mitochondria...
Accumulation of mitochondrial DNA (mtDNA) mutations leads to alterations of mitochondrial biogenesis...