Literature from the past two decades has outlined the existence of a trade-off between protein stability and function. This trade-off creates a unique challenge for protein engineers who seek to introduce new functionality to proteins. These engineers must carefully balance the mutation-mediated creation and/or optimization of function with the destabilizing effect of those mutations. Subsequent research has shown that protein stability is positively correlated with “evolvability” or the ability to support mutations which bestow new functionality on the protein. Since the ultimate goal of protein engineering is to create and/or optimize a protein’s function, highly stable proteins are preferred as potential scaffolds for p...
During the past 15 years there has been a continuous flow of reports describing proteins stabilized ...
AbstractEx vivo stability is a valuable protein characteristic but is laborious to improve experimen...
In any protein design endeavor, thermal stability is an important issue. Increasing protein stabilit...
Literature from the past two decades has outlined the existence of a trade-off between protein stabi...
Protein engineering is a powerful tool for the improvement of the properties of biocatalysts, Previo...
Protein engineering strategies for increasing stability can be improved by replacing random mutagene...
Many proteins are rapidly deactivated when exposed to high or even ambient temperatures. This cannot...
Elucidation of evolutionary factors that enhance protein thermostability is a critical problem and w...
<div><p>Engineering protein molecules with desired structure and biological functions has been an el...
International audienceProteins from thermophilic and hyperthermophilic organisms are stable and func...
Protein thermostability is an important field for its evolutionary perspective of mesophilic versus ...
The ability to add noncanonical amino acids to the genetic code may allow one to evolve proteins wit...
Organisms that thrive under extreme conditions, such as high salt concentration, low pH, or high tem...
rotein engineering is a multidisciplinary approach to study the properties of proteins, combining co...
The ability to use proteins in nonnatural environments greatly expands their potential applications ...
During the past 15 years there has been a continuous flow of reports describing proteins stabilized ...
AbstractEx vivo stability is a valuable protein characteristic but is laborious to improve experimen...
In any protein design endeavor, thermal stability is an important issue. Increasing protein stabilit...
Literature from the past two decades has outlined the existence of a trade-off between protein stabi...
Protein engineering is a powerful tool for the improvement of the properties of biocatalysts, Previo...
Protein engineering strategies for increasing stability can be improved by replacing random mutagene...
Many proteins are rapidly deactivated when exposed to high or even ambient temperatures. This cannot...
Elucidation of evolutionary factors that enhance protein thermostability is a critical problem and w...
<div><p>Engineering protein molecules with desired structure and biological functions has been an el...
International audienceProteins from thermophilic and hyperthermophilic organisms are stable and func...
Protein thermostability is an important field for its evolutionary perspective of mesophilic versus ...
The ability to add noncanonical amino acids to the genetic code may allow one to evolve proteins wit...
Organisms that thrive under extreme conditions, such as high salt concentration, low pH, or high tem...
rotein engineering is a multidisciplinary approach to study the properties of proteins, combining co...
The ability to use proteins in nonnatural environments greatly expands their potential applications ...
During the past 15 years there has been a continuous flow of reports describing proteins stabilized ...
AbstractEx vivo stability is a valuable protein characteristic but is laborious to improve experimen...
In any protein design endeavor, thermal stability is an important issue. Increasing protein stabilit...