Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of major depressive disorder (MDD). However, the cellular origin of inflammatory signals and their specificity remain unclear. We examined the phenotype and glucocorticoid signaling in key cell populations of the innate immune system (monocytes) vs. adaptive immunity (T cells) in a sample of 35 well-characterized, antidepressant-free patients with MDD and 35 healthy controls individually matched for age, sex, smoking status and body mass index. Monocyte and T cell phenotype was assessed by flow cytometry. Cell-specific steroid signaling was determined by mRNA expression of pre-receptor regulation (11β-hydroxysteroid dehydrogenase type 1; 11β -HSD1)...
Circulating monocytes contribute to inflammatory processes. We here validate abnormal expression of ...
Major depressive disorder (MDD) is a prevalent and debilitating disorder, often fatal. Treatment opt...
It is now well established that major depression is accompanied and characterized by altered respons...
Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of maj...
Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of maj...
In this study, we used new technology to investigate whether a coherent pattern of enhanced expressi...
It is now well established that major depression is accompanied and characterized by altered respons...
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the CNS with a high prevalence ...
<p>While a link between inflammation and the development of neuropsychiatric disorders, including ma...
BackgroundPeripheral inflammation is often associated with major depressive disorder (MDD), and immu...
While a link between inflammation and the development of neuropsychiatric disorders, including major...
Background Peripheral inflammation is often associated with major depressive disorder (MDD), and imm...
The current study evaluated the relationship between stress-related psychiatric disorders, (major de...
While a link between inflammation and the development of neuropsychiatric disorders, including majo...
Introduction: Major depressive disorder (MDD) patients experience a systemic inflammatory stage. Mon...
Circulating monocytes contribute to inflammatory processes. We here validate abnormal expression of ...
Major depressive disorder (MDD) is a prevalent and debilitating disorder, often fatal. Treatment opt...
It is now well established that major depression is accompanied and characterized by altered respons...
Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of maj...
Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of maj...
In this study, we used new technology to investigate whether a coherent pattern of enhanced expressi...
It is now well established that major depression is accompanied and characterized by altered respons...
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the CNS with a high prevalence ...
<p>While a link between inflammation and the development of neuropsychiatric disorders, including ma...
BackgroundPeripheral inflammation is often associated with major depressive disorder (MDD), and immu...
While a link between inflammation and the development of neuropsychiatric disorders, including major...
Background Peripheral inflammation is often associated with major depressive disorder (MDD), and imm...
The current study evaluated the relationship between stress-related psychiatric disorders, (major de...
While a link between inflammation and the development of neuropsychiatric disorders, including majo...
Introduction: Major depressive disorder (MDD) patients experience a systemic inflammatory stage. Mon...
Circulating monocytes contribute to inflammatory processes. We here validate abnormal expression of ...
Major depressive disorder (MDD) is a prevalent and debilitating disorder, often fatal. Treatment opt...
It is now well established that major depression is accompanied and characterized by altered respons...