BETEL LEAF EXTRACTS (PIPER BETLE L.) PREVENT ENDOTHELIAL DYSFUNCTION BY REDUCING THE LEVELS OF URIC ACID AND ICAM-1 EXPRESSION OF THE HYPERURICEMIA WISTAR RATS (RATTUS NORVEGICUS) AORTIC ENDOTHELIAL

Hyperuricemia as a risk factor for cardiovascular disease causes endothelial dysfunction by increasing oxidative stress and inflammation. Extracts of betel leaf (Piper betle L.) contain bioactivity as an antioxidant, anti-inflammatory and XO inhibitor. The aim of the research is to determine the betel leaf extracts can prevent endothelial dysfunction caused by hyperuricemia by lowering uric acid levels and the expression of ICAM-1 endothelial aorta. The experimental research was conducted by the design of The Post Test Only Randomized Control Group Dsign, performed on untreated animals and rats fed with oxonic potassium (hyperuricemia), and compared to hyperuricemic rats treated with either betel leaf extract or allopurinol. After the experiment, the blood uric acid levels and the expression of aortic endothelial ICAM-1 were determined. The research results showed that the betel leaf extract lowered significantly (p <0.05) the blood uric acid levels and the expression of ICAM-1, rat aortic endothelial hyperuricemia. There is a positive correlation between the levels of uric acid with the expression of aortic endothelial ICAM-1 (p <0.05). It can be concluded that the betel leaf extracts can prevent endothelial dysfunction caused by hyperuricemia by lowering the uric acid levels and the expression of ICAM-1 aortic endothelial.