Abstract We discuss consequences of the ’t Hooft anomaly matching condition for Quantum Chromodynamics (QCD) with massless fundamental quarks. We derive the new discrete ’t Hooft anomaly of massless QCD for generic numbers of color N c and flavor N f , and an exotic chiral-symmetry broken phase without quark-bilinear condensate is ruled out from possible QCD vacua. We show that the U(1)B baryon number symmetry is anomalously broken when the ℤ2NfA $$ {\left({\mathrm{\mathbb{Z}}}_{2{N}_{\mathrm{f}}}\right)}_{\mathrm{A}} $$ discrete axial symmetry and the flavor symmetry are gauged. In the ordinary chiral symmetry breaking, the Skyrmion current turns out to reproduce this ’t Hooft anomaly of massless QCD. In the exotic chiral symmetry breaking...