Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study
- Núria Mallorquí-Bagué
- María Lozano-Madrid
- Estefanía Toledo
- Dolores Corella
- Jordi Salas-Salvadó
- Aida Cuenca-Royo
- Jesús Vioque
- Dora Romaguera
- J. Alfredo Martínez
- Julia Wärnberg
- José López-Miranda
- Ramón Estruch
- Aurora Bueno-Cavanillas
- Ángel Alonso-Gómez
- Josep A. Tur
- Francisco J. Tinahones
- Lluís Serra-Majem
- Vicente Martín
- José Lapetra
- Clotilde Vázquez
- Xavier Pintó
- Josep Vidal
- Lidia Daimiel
- José J. Gaforio
- Pilar Matía
- Emilio Ros
- Roser Granero
- Pilar Buil-Cosiales
- Rocío Barragán
- Mònica Bulló
- Olga Castañer
- Manoli García-de-la-Hera
- Aina M. Yáñez
- Itziar Abete
- Antonio García-Ríos
- Miguel Ruiz-Canela
- Andrés Díaz-López
- Susana Jiménez-Murcia
- Miguel A. Martínez-González
- Rafael De la Torre
- Fernando Fernández-Aranda
DOIAbstract
Abstract This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect n...
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