Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection

We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved. Keywords: Cutaneous Scedosporium apiospermum, Voriconazole, Trough, Transplant, Immunocompromise