Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental contaminants, known to affect T lymphocytes. However, the molecular targets and pathways involved in their immunotoxic effects in human T lymphocytes remain unknown. Here, we analyzed the gene expression profile of primary human T lymphocytes treated with the prototypical PAH, benzo[α]pyrene (B[α]P), using a microarray-based transcriptome analysis. After a 48 h exposure to B[α]P, we identified 158 genes differentially expressed in T lymphocytes, including not only genes well-known to be affected by PAHs such as the cytochromes P450 (CYP) 1A1 and 1B1, but also others not previously shown to be targeted by B[α]P such as genes encoding the gap junc...
Phenanthrene (Phe), a polycyclic aromatic hydrocarbon (PAH), is a major constituent of urban air pol...
Although the activation of immune cells is the first and thereby pivotal step in the immunological c...
AbstractPolycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental ...
International audiencePolycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental c...
International audiencePolycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are w...
Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (B[a]P), are ubiquitous environmenta...
International audiencePolycyclic aromatic hydrocarbons (PAHs) are widely distributed immunotoxic and...
Les hydrocarbures aromatiques polycycliques (HAPs), tels que le benzo(a)pyrène (B[a]P), sont des con...
There is a clear evidence that environmental pollutants, such as benzo[a]pyrene (B[a]P), can have de...
BACKGROUND: The AhR is a ligand-activated transcription factor that mediates immunosuppression induc...
Abstract Background The AhR is a ligand-activated transcription factor that mediates immunosuppressi...
Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP) are ubiquitous environmental co...
International audienceThe aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor...
Intensive research during the past decade has highlighted the impact of the regulatory function of t...
Although the activation of immune cells is the first and thereby pivotal step in the immunological c...
Phenanthrene (Phe), a polycyclic aromatic hydrocarbon (PAH), is a major constituent of urban air pol...
Although the activation of immune cells is the first and thereby pivotal step in the immunological c...
AbstractPolycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental ...
International audiencePolycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental c...
International audiencePolycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are w...
Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (B[a]P), are ubiquitous environmenta...
International audiencePolycyclic aromatic hydrocarbons (PAHs) are widely distributed immunotoxic and...
Les hydrocarbures aromatiques polycycliques (HAPs), tels que le benzo(a)pyrène (B[a]P), sont des con...
There is a clear evidence that environmental pollutants, such as benzo[a]pyrene (B[a]P), can have de...
BACKGROUND: The AhR is a ligand-activated transcription factor that mediates immunosuppression induc...
Abstract Background The AhR is a ligand-activated transcription factor that mediates immunosuppressi...
Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP) are ubiquitous environmental co...
International audienceThe aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor...
Intensive research during the past decade has highlighted the impact of the regulatory function of t...
Although the activation of immune cells is the first and thereby pivotal step in the immunological c...
Phenanthrene (Phe), a polycyclic aromatic hydrocarbon (PAH), is a major constituent of urban air pol...
Although the activation of immune cells is the first and thereby pivotal step in the immunological c...
AbstractPolycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental ...