Colon cancer represents the third most common malignancy worldwide. New drugs with high efficaciousness and safety for the treatment of colon cancer are urgently needed in clinical context. Here, we were aimed to evaluate the antitumor activity of the natural compound α-hederin in human colon cancer cells. We treated SW620 cells with interleukin-6 (IL-6) in vitro to mimic the paracrine inflammatory microenvironment of tumor cells. α-Hederin concentration dependently reduced the viability of IL-6-stimulated SW620 cells. α-Hederin increased the number of IL-6-stimulated SW620 cells at the G2/M phase and reduced the mRNA and protein expression of cyclin B1 and CDK1. Moreover, α-hederin induced apoptosis and loss of mitochondrial membrane poten...
BackgroundThe activation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) sti...
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy....
Background: Colon cancers are the frequent causes of cancer mortality worldwide. Recently bacterial ...
Background: Oral cancer is one of the common malignant tumors of the head and neck. However, current...
Chemoresistance is a major limiting factor that impairs the outcome of non-small cell lung cancer (N...
The current anti-cancer treatments are not enough to eradicate tumors, and therefore, new modalities...
There is growing interest in development of natural products as anti-cancer and chemopreventive agen...
Hesperidin, a flavonoid found mainly in citrus, was reported to inhibit growth and proliferation of ...
Colorectal cancer (CRC) is a major cause of mortality and morbidity. Chronic inflammation is closely...
Colon cancer is a common cause of cancer-related death worldwide. However, the underlying mechanism ...
Colon cancer is a relatively common malignant tumor of the digestive tract. Currently, most colon ca...
Depression is a prevalent psychiatric disorder and a leading cause of disability worldwide. Despite ...
Therapy of colon cancer by using 5-FU often causes problems of resistance. This encourages the devel...
Background. The heterocyclic scaffolds are in the list of key structural blocks used at synthesis of...
Effective immunomodulator and pro-inflammatory cytokine, Tumor necrosis factor-α (TNF-α) are conside...
BackgroundThe activation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) sti...
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy....
Background: Colon cancers are the frequent causes of cancer mortality worldwide. Recently bacterial ...
Background: Oral cancer is one of the common malignant tumors of the head and neck. However, current...
Chemoresistance is a major limiting factor that impairs the outcome of non-small cell lung cancer (N...
The current anti-cancer treatments are not enough to eradicate tumors, and therefore, new modalities...
There is growing interest in development of natural products as anti-cancer and chemopreventive agen...
Hesperidin, a flavonoid found mainly in citrus, was reported to inhibit growth and proliferation of ...
Colorectal cancer (CRC) is a major cause of mortality and morbidity. Chronic inflammation is closely...
Colon cancer is a common cause of cancer-related death worldwide. However, the underlying mechanism ...
Colon cancer is a relatively common malignant tumor of the digestive tract. Currently, most colon ca...
Depression is a prevalent psychiatric disorder and a leading cause of disability worldwide. Despite ...
Therapy of colon cancer by using 5-FU often causes problems of resistance. This encourages the devel...
Background. The heterocyclic scaffolds are in the list of key structural blocks used at synthesis of...
Effective immunomodulator and pro-inflammatory cytokine, Tumor necrosis factor-α (TNF-α) are conside...
BackgroundThe activation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) sti...
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy....
Background: Colon cancers are the frequent causes of cancer mortality worldwide. Recently bacterial ...