The resident microglial and infiltrating cells from peripheral circulation are involved in the pathological processes of ischemia stroke and may be regulated by mesenchymal stem/stromal cell (MSC) transplantation. The present study is aimed at differentiating the neurotrophic and inflammatory roles played by microglial vs. infiltrating circulation-derived cells in the acute phase in rat ischemic brains and explore the influences of intravenously infused allogeneic MSCs. The ischemic brain injury was induced by distal middle cerebral artery occlusion (dMCAO) in SD rats, with or without MSC infusion in the same day following dMCAO. Circulation-derived infiltrating cells in the brain were identified by Ly6C, a majority of which were monocytes/...
Abstract Background Adipose-derived mesenchymal stem cell (ADMSC) therapy can promote recovery from ...
Neural stem cell (NSC) transplantation has been investigated as a means to reconstitute the damaged ...
Our previous studies showed that bone marrow mononuclear cells (BMMNCs) from 5-fluorouracil (5-FU) p...
Recent studies report that inhibiting TNF-α might be a novel therapeutic strategy for managing brain...
Background and Purpose. Previously, we found that insulin-like growth factor-1 (IGF-1) levels in the...
Microglia are resident immunocompenent and phagocytic cells of central nervous system (CNS), which p...
Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However...
Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However...
Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However...
The middle cerebral artery occlusion (MCAO) model has been extensively applied to study ischaemic st...
Background: Ischemic stroke is a major cause of permanent disability and inflammation has a prominen...
Systemic transplantation of mesenchymal stem cells (MSCs) is a promising approach for the treatment ...
Background: Ischemic stroke is a major cause of permanent disability and inflammation has a prominen...
AbstractTransplantation of mesenchymal stem cells (MSCs) has been shown to enhance the recovery of b...
There is now evidence to suggest that bone marrow mesenchymal stem cells (MSCs) not only differentia...
Abstract Background Adipose-derived mesenchymal stem cell (ADMSC) therapy can promote recovery from ...
Neural stem cell (NSC) transplantation has been investigated as a means to reconstitute the damaged ...
Our previous studies showed that bone marrow mononuclear cells (BMMNCs) from 5-fluorouracil (5-FU) p...
Recent studies report that inhibiting TNF-α might be a novel therapeutic strategy for managing brain...
Background and Purpose. Previously, we found that insulin-like growth factor-1 (IGF-1) levels in the...
Microglia are resident immunocompenent and phagocytic cells of central nervous system (CNS), which p...
Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However...
Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However...
Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However...
The middle cerebral artery occlusion (MCAO) model has been extensively applied to study ischaemic st...
Background: Ischemic stroke is a major cause of permanent disability and inflammation has a prominen...
Systemic transplantation of mesenchymal stem cells (MSCs) is a promising approach for the treatment ...
Background: Ischemic stroke is a major cause of permanent disability and inflammation has a prominen...
AbstractTransplantation of mesenchymal stem cells (MSCs) has been shown to enhance the recovery of b...
There is now evidence to suggest that bone marrow mesenchymal stem cells (MSCs) not only differentia...
Abstract Background Adipose-derived mesenchymal stem cell (ADMSC) therapy can promote recovery from ...
Neural stem cell (NSC) transplantation has been investigated as a means to reconstitute the damaged ...
Our previous studies showed that bone marrow mononuclear cells (BMMNCs) from 5-fluorouracil (5-FU) p...