Background: Lymphocytes activated by immunization must increase their metabolism to meet the energy requirements for mitosis, differentiation, and protein synthesis, which may subject the cell to conditions of relative hypoxia and oxidative stress. This study was conducted to investigate the increase in the levels of transcription factors involved in both conditions. Methods: Male Balb/c mice were divided into the following four groups, each consisting of six animals: the control and three experimental groups. The experimental groups were immunized by injection of 0.2 ml of 2% sheep red blood cells (SRBC) suspended in phosphate-buffered saline (PBS). Lymphocytes were harvested from the spleens of each group at time intervals of 24-, 48-, a...
<div><p>Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of v...
Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to inadequate tiss...
Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of various g...
BACKGROUND Activated macrophages require increased oxygen to destroy foreign bodies, leading to an i...
Abstract: Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid h...
BackgroundHypoxia training enhances the endurance capacity of athletes. This response may in part be...
Dendritic cells (DC) play a key role in linking innate and adaptive immunity. In inflamed tissues, w...
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes, which regu...
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regul...
Hypoxia occurs in normal, healthy tissues as well as during a wide variety of pathological events, a...
Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid hormones T3...
Dendritic cells (DC) play a key role in linking innate and adaptive immunity. In inflamed tissues, w...
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF...
Murine lymph node cells (LNC) were used as model for the assessment of a role for reactive oxygen s...
The ability of cells to sense and adapt to changes in oxygen is mediated by hypoxia-inducible factor...
<div><p>Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of v...
Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to inadequate tiss...
Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of various g...
BACKGROUND Activated macrophages require increased oxygen to destroy foreign bodies, leading to an i...
Abstract: Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid h...
BackgroundHypoxia training enhances the endurance capacity of athletes. This response may in part be...
Dendritic cells (DC) play a key role in linking innate and adaptive immunity. In inflamed tissues, w...
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes, which regu...
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regul...
Hypoxia occurs in normal, healthy tissues as well as during a wide variety of pathological events, a...
Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid hormones T3...
Dendritic cells (DC) play a key role in linking innate and adaptive immunity. In inflamed tissues, w...
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF...
Murine lymph node cells (LNC) were used as model for the assessment of a role for reactive oxygen s...
The ability of cells to sense and adapt to changes in oxygen is mediated by hypoxia-inducible factor...
<div><p>Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of v...
Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to inadequate tiss...
Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of various g...