Helicobacter Pylori in functional dyspepsia

Background and Objective: After distinguishing the role of Helicobacter Pylori in gastritis and peptic ulcer, some hypothesis were brought up about the probable interference of this germ in dyspepsia. This study was done in order to determine the prevalence of Helicobacter Pylori infection in persons conflicted with dyspepsia, attended in 5th Azar Hospital in Gorgan during 8 months (From 2001/Mar/21 to 2001/Nov/22). Materials and Methods: In this research, 270 patients with diagnosis of dyspepsia were endoscopic based on clinical examinations and paraclinical studies and after ruling out of erosive gastrodeodenitis and peptic ulcer, two biopsy samples were taken from antrum. Then, the samples were put in urea rapid test environment media. The required time for positive response was 15 minutes but to be completely sure about it, urea environment media consisted of biopsy samples were maintained for 2 hours. Any color changes during this time were considered as positive response. Results: Among 270 patients conflicted with dyspepsia 136 patties were male and 134 were female with age average of 40.9% Y/O. The patients with Helicobacter Pylori infection were 139 (51.5%) and the ones without infection were 131 (48.5%), and age averages were 44.4 Y/O and 37.3 Y/O, respectively. The prevalence of dyspepsia subgroups were as follows: Ulcer like 53.7%, reflux like 31.1%, non specific 9.6%, and dismotility like 5.6%, and the prevalence of infection among dyspepsia subgroups were as follows: Ulcer like 62.02%, reflux like 40.47%, non specific 46.15%, and dismotility like 20%. Other risk factors in these patients were as follows: Cigarette smoking 25.6%, NSAID 16.3% and alcohol drinking 4.1%. Conclusion: This study suggests that Helicobacter Pylori infection can have a role in formation of dyspepsia