Etoposide is widely used in the chemotherapy of a variety of malignancies. But the strong lipophilicity, poor bioavailability, and severe side effects of etoposide limit its clinical application. The aim of this study was to develop sustained-release etoposide-loaded implants and evaluate antitumor activity of the implants after intratumoral implantation. We prepared the implants containing etoposide, poly(L-lactid acid) and polyethylene glycol 4000 by the direct compression method. The implants were characterized regarding drug-excipient compatibility, content uniformity, morphology, sterility, in vitro, and in vivo release profiles. Then the antitumor activity of the implants was tested in xenograft model of A549 human non-small cell lung...
Jiao Wang,1 Rongrong Zhu,1 Xiaoyu Sun,1 Yanjing Zhu,1 Hui Liu,2 Shi-Long Wang1 1Research Center for...
INTRODUCTION Polymer-based delivery systems offer innovative intra-cavity administration of drugs...
In the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene g...
Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cance...
Li Gao,1,2 Lunyang Xia,3 Ruhui Zhang,1 Dandan Duan,3 Xiuxiu Liu,2 Jianjian Xu,2 Lan Luo1 1State Key...
Etoposide-loaded poly(lactic-co-glycolic acid) implants were developed for intravitreal application....
Etoposide has been shown to be effective in the treatment of testicular and small-cell lung cancers,...
Cisplatin is the most commonly used antitumor drug in the chemotherapy of a variety of malignancies....
<p>Mice were sacrificed 3 days after implantation of either blank (A-B) or etoposide-loaded (C-D) po...
Poor solubility of etoposide and associated poor bioavailability of the drug was circumvented by dev...
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been extensively used in cancer research. PLGA...
INTRODUCTION:Polymer-based delivery systems offer innovative intra-cavity administration of drugs, w...
Introduction The median survival of patients with glioblastoma multiforme (astrocytoma grade 4) rem...
Min Du,1 Jianbo Yin2 1Department of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jian...
Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the poten...
Jiao Wang,1 Rongrong Zhu,1 Xiaoyu Sun,1 Yanjing Zhu,1 Hui Liu,2 Shi-Long Wang1 1Research Center for...
INTRODUCTION Polymer-based delivery systems offer innovative intra-cavity administration of drugs...
In the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene g...
Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cance...
Li Gao,1,2 Lunyang Xia,3 Ruhui Zhang,1 Dandan Duan,3 Xiuxiu Liu,2 Jianjian Xu,2 Lan Luo1 1State Key...
Etoposide-loaded poly(lactic-co-glycolic acid) implants were developed for intravitreal application....
Etoposide has been shown to be effective in the treatment of testicular and small-cell lung cancers,...
Cisplatin is the most commonly used antitumor drug in the chemotherapy of a variety of malignancies....
<p>Mice were sacrificed 3 days after implantation of either blank (A-B) or etoposide-loaded (C-D) po...
Poor solubility of etoposide and associated poor bioavailability of the drug was circumvented by dev...
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been extensively used in cancer research. PLGA...
INTRODUCTION:Polymer-based delivery systems offer innovative intra-cavity administration of drugs, w...
Introduction The median survival of patients with glioblastoma multiforme (astrocytoma grade 4) rem...
Min Du,1 Jianbo Yin2 1Department of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jian...
Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the poten...
Jiao Wang,1 Rongrong Zhu,1 Xiaoyu Sun,1 Yanjing Zhu,1 Hui Liu,2 Shi-Long Wang1 1Research Center for...
INTRODUCTION Polymer-based delivery systems offer innovative intra-cavity administration of drugs...
In the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene g...