Abstract Background Changes in iron metabolism frequently accompany HIV-1 infection. However, while many clinical and in vitro studies report iron overload exacerbates the development of infection, many others have found no correlation. Therefore, the multi-faceted role of iron in HIV-1 infection remains enigmatic. Methods RT-qPCR targeting the LTR region, gag, Tat and Rev were performed to measure the levels of viral RNAs in response to iron overload. Spike-in SILAC proteomics comparing i) iron-treated, ii) HIV-1-infected and iii) HIV-1-infected/iron treated T lymphocytes was performed to define modifications in the host cell proteome. Data from quantitative proteomics were integrated with the HIV-1 Human Interaction Database for assessing...
HIV-1 persists in a latent form during antiretroviral therapy, mainly in CD4+ T cells, thus hamperin...
International audienceBACKGROUND: Increased cellular iron levels are associated with high mortality ...
BACKGROUND: Iron-related genes and iron status may independently contribute to variable HIV outcomes...
BACKGROUND: Changes in iron metabolism frequently accompany HIV-1 infection. However, while many cl...
Background Changes in iron metabolism frequently accompany HIV-1 infection. However, while many c...
Iron is essential for almost all biological systems and its metabolism is perturbed during infection...
Despite efficient antiretroviral therapy, eradication of HIV-1 infection is challenging and requires...
Background: Physiological regulation of cellular iron involves iron export by the membrane protein, ...
Many severe clinical conditions encountered in Africa involve the effects of iron overload on diseas...
The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef...
There had been conflicting reports with levels of markers of iron metabolism in HIV infection. This ...
Fundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Vi...
Background: Theoretical considerations and experiments in the laboratory suggest that excessive iron...
HIV-1 transcription is activated by the Tat protein, which recruits CDK9/cyclin T1 to the HIV-1 prom...
Iron depletion by iron chelators or ferroportin inhibits HIV-1 through the induction of HIF1a, p21 a...
HIV-1 persists in a latent form during antiretroviral therapy, mainly in CD4+ T cells, thus hamperin...
International audienceBACKGROUND: Increased cellular iron levels are associated with high mortality ...
BACKGROUND: Iron-related genes and iron status may independently contribute to variable HIV outcomes...
BACKGROUND: Changes in iron metabolism frequently accompany HIV-1 infection. However, while many cl...
Background Changes in iron metabolism frequently accompany HIV-1 infection. However, while many c...
Iron is essential for almost all biological systems and its metabolism is perturbed during infection...
Despite efficient antiretroviral therapy, eradication of HIV-1 infection is challenging and requires...
Background: Physiological regulation of cellular iron involves iron export by the membrane protein, ...
Many severe clinical conditions encountered in Africa involve the effects of iron overload on diseas...
The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef...
There had been conflicting reports with levels of markers of iron metabolism in HIV infection. This ...
Fundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Vi...
Background: Theoretical considerations and experiments in the laboratory suggest that excessive iron...
HIV-1 transcription is activated by the Tat protein, which recruits CDK9/cyclin T1 to the HIV-1 prom...
Iron depletion by iron chelators or ferroportin inhibits HIV-1 through the induction of HIF1a, p21 a...
HIV-1 persists in a latent form during antiretroviral therapy, mainly in CD4+ T cells, thus hamperin...
International audienceBACKGROUND: Increased cellular iron levels are associated with high mortality ...
BACKGROUND: Iron-related genes and iron status may independently contribute to variable HIV outcomes...