Catheter-related Bloodstream Infection Rates, Distribution Of Infective Agents and Antibiotic Susceptibilities In Intensive Care Units: Results Of a 5.5-Year-Study

Introduction: Catheter-related infections and resistance to antimicrobials represent challenge in care units especially designed for high risk patients. Central venous catheter-related bloodstream infections due to multidrug resistant gram negative bacteria (CVC-r BSI) tend to increase. We aimed to investigate bloodstream infections rate related to central venous catheter, detect pathogens and antibiotic sensitivity status in our Intensive Care Units (ICU). Materials and Methods: This study included patients with CVC-r BSI in our ICUs between January 2008 and July 2013. Records of Infection Control Committee and patient fi les were retrospectively reviewed. Results: CVC-r BSI rate was 2-8 per 1000 catheter days in ICUs between 2008-2013. We detected a total of 172 isolates in 166 CVC-r BSI. Of all isolates, 52% were gram negative, 27% gram positive and 21% Candida spp. ESBL was found 54.5% in Klebsiellae pneumoniae, and only one isolate demonstrated carbapenem resistance (4.2%). Carbapenem resistance was 91% in Acinetobacter baumannii. Methycillin-resistant Staphylococcus aureus (MRSA) was detected as %66.7, Methycillin-resistant coagulase-negative staphylococcus (MR-KNS) 100%, and Vancomycin-resistant Enterococcus spp. 9.5%. Conclusion: Empirical therapy should be selected according to pathogens and their sensitivity results in ICUs reporting gram-negative microorganisms and higher resistance rates