Assessing the impact of oral iodine supplementation on whole body iodine store, thyroid autoimmunity and serum biochemistry profile in women of childbearing age

Background and aims: Iodine supplementation is advised for women with compromised iodine intake in the preconception period. The purpose of this study was to evaluate the benefits and harms of a supplementary dose of iodine (150 μg/day) for 90 days in women of childbearing age. Materials and methods: Non-pregnant females (n = 38; mean age: 24.1 ± 2.6 years; Range: 20–30) receiving a hall diet were enrolled. Measurements of urinary iodine excretion (UIC), thyroid autoimmunity biomarkers, serum clinical biochemistry profile and serum thyroglobulin were performed at baseline- and after iodine supplementation at 45- and 90 days, respectively. Results: Median UICs (μg/L) at baseline and after iodine intervention were 110, 304 and 310, respectively. This coincided with reductions in thyroglobulin, triacylglycerol, HDL-C, LDL-C, LDH, ALP and CPK levels as well as the prevalence of participants with UIC