Candida dubliniensis Infectious: Retrospective Evaluation

Introduction: Candida dubliniensis is morphologically similar to C. albicans, but it can be an important yeast because of resistance to fluconazole. In this study, patients who had C. Dubliniensis infection were evaluated in terms of risk factors, underlying diseases, and responses to treatment. Patients and Methods: Fifteen patients identifi ed with C. dubliniensis as an infection factor in any microbiological sample were evaluated retrospectively between 2004-2013 in our hospital. Blood cultures of seven patients, respiratory samples of six patients with a high Candida score or consideration of invasive fungal infection, esophageal biopsyspecimen of a patient and urinec ulture of a patient were positive. The most frequent underlying diseases were malignancy, heart failure, and immunosupsession, respectively. Intensive care hospitalization, central venous and urinary catheter and total parenteral nutrition were found as risk factors as they are in other Candida infections. Fluconazole for seven patients, caspofungin for three patients, voriconazole for two patients, amphotericin B for two patients, and anidulafungin for one patient were given as antifungal treatment. Seven patients with severe underlying diseases died. Results: Blood cultures in seven patients, respiratory samples in six patients with a high candida score or consideration of invasive fungal infection, esophageal biopsy specimen in a patient and urine culture in a patient were positive. The most frequent underlying diseases were malignancy, heart failure, and immunosupsession. Intensive care hospitalization, central venous and urinary catheter, and total parenteral nutrition were found as risk factors similar to those in other candida infections risk factors. Fluconazole in seven patients, caspofungin in three patients, voriconazole in two patients, amphotericin B in two patients, and anidulafungin in one patient were given as antifungal therapy. Seven patients with severe underlying diseases died. Conclusion: This is the first report in our country, which evaluated patients infected with C. dubliniensis. C. dubliniensis can cause invasive infections in patients with underlying disease or risk factors and fl uconazole resistance andmortality should be kept in mind