Abstract Background Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines suggest glycaemic targets be relaxed in advanced diabetes. We explored whether disease duration or pre-existing macrovascular complications attenuated the association between hyperglycaemia and microvascular function. Methods 743 participants with T2DM (n = 222), cardiovascular disease (CVD = 183), both (n = 177) or neither (controls = 161) from two centres in the UK, underwent standard clinical measures and endothelial dependent (ACh) and independent (SNP) microvascular function assessment using laser Doppler imaging. Results People with T2DM and CVD had attenuated ACh and SNP responses compared to controls. This was addit...
BACKGROUND: Strict glycaemic control in patients with type 2 diabetes has proven to have microvascul...
Background: Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular disease. T...
Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular e...
Background: Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current ...
Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines s...
Background Coronary microvascular dysfunction (CMD) is associated with cardiovascular events in typ...
Background Diabetes confers a two times excess risk of cardiovascular disease, yet predicting indivi...
Diabetes confers a two times excess risk of cardiovascular disease, yet predicting individual risk r...
AbstractObjectivesWe sought to determine the differences in coronary microvascular function between ...
Objective: Type 2 diabetes mellitus (T2DM) is known to be associated with increased cardiovascular r...
Abstract Background Patients with type 2 diabetes mellitus are at an increased risk of adverse cardi...
ObjectiveTo assess whether the presence of microvascular complications modifies the effect of intens...
OBJECTIVE: To determine the relation between exposure to glycaemia over time and the risk of macrova...
OBJECTIVE: Poor glycemic control is related to vascular events in patients with type 2 diabetes, but...
Diabetes complications increase with disease duration. No study was performed on the relationship be...
BACKGROUND: Strict glycaemic control in patients with type 2 diabetes has proven to have microvascul...
Background: Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular disease. T...
Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular e...
Background: Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current ...
Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines s...
Background Coronary microvascular dysfunction (CMD) is associated with cardiovascular events in typ...
Background Diabetes confers a two times excess risk of cardiovascular disease, yet predicting indivi...
Diabetes confers a two times excess risk of cardiovascular disease, yet predicting individual risk r...
AbstractObjectivesWe sought to determine the differences in coronary microvascular function between ...
Objective: Type 2 diabetes mellitus (T2DM) is known to be associated with increased cardiovascular r...
Abstract Background Patients with type 2 diabetes mellitus are at an increased risk of adverse cardi...
ObjectiveTo assess whether the presence of microvascular complications modifies the effect of intens...
OBJECTIVE: To determine the relation between exposure to glycaemia over time and the risk of macrova...
OBJECTIVE: Poor glycemic control is related to vascular events in patients with type 2 diabetes, but...
Diabetes complications increase with disease duration. No study was performed on the relationship be...
BACKGROUND: Strict glycaemic control in patients with type 2 diabetes has proven to have microvascul...
Background: Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular disease. T...
Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular e...