Junctional epidermolysis bullosa (JEB) is a hereditary blistering disease caused by reduced dermal-epidermal adhesion due to deficiencies of one of the proteins, laminin-332, type XVII collagen, integrin α6β4 or integrin α3. Significant progress has been achieved in the development of therapies for EB, such as bone-marrow transplantation, local or systemic injections with fibroblasts or mesenchymal stromal cells, readthrough of premature termination codons, or exon skipping. These were tailored in particular for dystrophic EB, which is caused by type VII collagen deficiency and have not yet reached broad clinical practice. Recently, pioneering combined gene and stem cell therapy was successful in treating one boy with junctional EB. Beside ...
Mutations in the type XVII collagen gene (COL17A1) result in the blistering disorder non-Herlitz jun...
Junctional epidermolysis bullosa (JEB) is a genodermatosis suitable for gene therapy because convent...
BP180/collagen XVII is a hemidesmosomal transmembrane molecule serving as cell-surface receptor. Mut...
SummaryJunctional epidermolysis bullosa (JEB) is a clinically and biologically heterogeneous genoder...
Junctional epidermolysis bullosa is a heritable, heterogeneous blistering skin disease with mechanic...
Epidermolysis bullosa (EB) is a devastating genetic skin disease typified by a plethora of different...
Epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of blistering disorde...
SummaryJunctional epidermolysis bullosa (JEB), a genetically heterogeneous group of blistering skin ...
Epidermolysis Bullosa (EB) is a group of inherited blistering disorders in response to mechanical tr...
Keratinocytes and dermal fibroblasts express adhesive proteins that ensure the epidermis remains att...
Background Mutations in the gene COL17A1 coding for type XVII collagen cause non-Herlitz junctional ...
Junctional epidermolysis bullosa (JEB) is a rare autosomal recessive genodermatosis with a broad spe...
Mutations in the COL17A1 gene lead to the genetic blistering disorder junctional epidermolysis bullo...
Epidermolysis bullosa (EB) is a group of devastating genetic diseases characterized by skin and muco...
Although rare genodermatoses such as Epidermolysis bullosa have received more attention over the las...
Mutations in the type XVII collagen gene (COL17A1) result in the blistering disorder non-Herlitz jun...
Junctional epidermolysis bullosa (JEB) is a genodermatosis suitable for gene therapy because convent...
BP180/collagen XVII is a hemidesmosomal transmembrane molecule serving as cell-surface receptor. Mut...
SummaryJunctional epidermolysis bullosa (JEB) is a clinically and biologically heterogeneous genoder...
Junctional epidermolysis bullosa is a heritable, heterogeneous blistering skin disease with mechanic...
Epidermolysis bullosa (EB) is a devastating genetic skin disease typified by a plethora of different...
Epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of blistering disorde...
SummaryJunctional epidermolysis bullosa (JEB), a genetically heterogeneous group of blistering skin ...
Epidermolysis Bullosa (EB) is a group of inherited blistering disorders in response to mechanical tr...
Keratinocytes and dermal fibroblasts express adhesive proteins that ensure the epidermis remains att...
Background Mutations in the gene COL17A1 coding for type XVII collagen cause non-Herlitz junctional ...
Junctional epidermolysis bullosa (JEB) is a rare autosomal recessive genodermatosis with a broad spe...
Mutations in the COL17A1 gene lead to the genetic blistering disorder junctional epidermolysis bullo...
Epidermolysis bullosa (EB) is a group of devastating genetic diseases characterized by skin and muco...
Although rare genodermatoses such as Epidermolysis bullosa have received more attention over the las...
Mutations in the type XVII collagen gene (COL17A1) result in the blistering disorder non-Herlitz jun...
Junctional epidermolysis bullosa (JEB) is a genodermatosis suitable for gene therapy because convent...
BP180/collagen XVII is a hemidesmosomal transmembrane molecule serving as cell-surface receptor. Mut...