Che-Ming Jack Hu,1,2,* You-Ting Chen,3,* Zih-Syun Fang,1,3 Wei-Shan Chang,3 Hui-Wen Chen2,3 1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 2Research Center for Nanotechnology and Infectious Diseases, Taipei, Taiwan; 3Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan *These authors contributed equally to this work Background: Influenza virus infections are a major public health concern worldwide. Conventional treatments against the disease are designed to target viral proteins. However, the emergence of viral variants carrying drug-resistant mutations can outpace the development of pathogen-targeting antivirals. Diphyllin and bafilomycin are potent vacuolar ATPase (V-ATPase) inhibitors prev...
Zhengfang Lin,1,* Yinghua Li,1,* Guifang Gong,2 Yu Xia,1 Changbing Wang,1 Yi Chen,1 Liang Hua,1 Jiay...
According to the Center for Disease Control and Prevention (CDC), the coronavirus disease 2019, a re...
Dongxi Xiang,1 Yang Zheng,2 Wei Duan,1 Xiujing Li,3 Jianjian Yin,3 Sarah Shigdar,1 Michael Liam O&rs...
An influenza pandemic poses a serious threat to humans and animals. Conventional treatments against ...
Influenza A viruses (IAVs) cause recurrent epidemics in humans, with serious threat of lethal worldw...
BACKGROUND AND PURPOSE: Cellular vacuolar ATPases (v-ATPase) play an important role in endosomal aci...
Influenza affects millions of people in all parts of the world. The fact that influenza virus can sp...
Influenza A virus infections impose a recurrent and global disease burden. Current antivirals agains...
In this study, we demonstrate the concept of "topology-matching design" for virus inhibitors. With t...
Background: Currently available anti-influenza drugs are often associated with limitations such as t...
Viral contaminations speak to a general medical issue and one of the main sources of worldwide morta...
In light of the recent novel H1N1 virus epidemic, virus resistance to currently approved antiviral m...
Viral-associated respiratory infectious diseases are one of the most prominent subsets of respirator...
The influenza (“flu”) type-A virus is a major medical and veterinary health concern and causes globa...
Viral-associated respiratory infectious diseases are one of the most prominent subsets of respirator...
Zhengfang Lin,1,* Yinghua Li,1,* Guifang Gong,2 Yu Xia,1 Changbing Wang,1 Yi Chen,1 Liang Hua,1 Jiay...
According to the Center for Disease Control and Prevention (CDC), the coronavirus disease 2019, a re...
Dongxi Xiang,1 Yang Zheng,2 Wei Duan,1 Xiujing Li,3 Jianjian Yin,3 Sarah Shigdar,1 Michael Liam O&rs...
An influenza pandemic poses a serious threat to humans and animals. Conventional treatments against ...
Influenza A viruses (IAVs) cause recurrent epidemics in humans, with serious threat of lethal worldw...
BACKGROUND AND PURPOSE: Cellular vacuolar ATPases (v-ATPase) play an important role in endosomal aci...
Influenza affects millions of people in all parts of the world. The fact that influenza virus can sp...
Influenza A virus infections impose a recurrent and global disease burden. Current antivirals agains...
In this study, we demonstrate the concept of "topology-matching design" for virus inhibitors. With t...
Background: Currently available anti-influenza drugs are often associated with limitations such as t...
Viral contaminations speak to a general medical issue and one of the main sources of worldwide morta...
In light of the recent novel H1N1 virus epidemic, virus resistance to currently approved antiviral m...
Viral-associated respiratory infectious diseases are one of the most prominent subsets of respirator...
The influenza (“flu”) type-A virus is a major medical and veterinary health concern and causes globa...
Viral-associated respiratory infectious diseases are one of the most prominent subsets of respirator...
Zhengfang Lin,1,* Yinghua Li,1,* Guifang Gong,2 Yu Xia,1 Changbing Wang,1 Yi Chen,1 Liang Hua,1 Jiay...
According to the Center for Disease Control and Prevention (CDC), the coronavirus disease 2019, a re...
Dongxi Xiang,1 Yang Zheng,2 Wei Duan,1 Xiujing Li,3 Jianjian Yin,3 Sarah Shigdar,1 Michael Liam O&rs...