Background: Several mechanisms of action have been proposed to explain the apparent antineoplastic functions of metformin, many of which are observed at high concentrations that may not be reflective of achievable tissue concentrations. We propose that metformin at low concentrations functions to inhibit ROS production and inflammatory signaling in breast cancer, thereby reducing metastasis. Methods: Using the highly invasive MDA-MB-231 breast carcinoma model, we ascertained the impact of metformin on cell viability by DNA content analysis and fluorescent dye exclusion. Migration and invasion assays were performed using a modified Boyden chamber assay and metastasis was ascertained using the chorioallantoic membrane (CAM) assay. PGE2 produc...
International audienceMetformin was reported to inhibit the proliferation of many cancer cells, incl...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Background: Several mechanisms of action have been proposed to explain the apparent antineoplastic f...
Metformin has been one of the most widely prescribed oral medications for type II diabetes for over ...
Metformin, a widely prescribed anti-diabetic drug, shows anticancer activity in various cancer types...
Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer...
Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin pr...
Metformin is one of the most widely prescribed antidiabetics for type 2 diabetes. A critical role of...
Breast Cancer (BC) is the leading cause of cancer death in women. One BC subtype is very aggressive ...
PURPOSE: Inflammatory infiltration plays important roles in both carcinogenesis and metastasis. We a...
Epidemiology studies have found that type 2 diabetics treated with metformin are at a lower risk for...
Accumulating evidence suggests that metformin, used as an antidiabetic drug, possesses anti-cancer p...
There is a great and growing interest in the anti-cancer effects of the diabetes drug metformin as e...
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs ta...
International audienceMetformin was reported to inhibit the proliferation of many cancer cells, incl...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Background: Several mechanisms of action have been proposed to explain the apparent antineoplastic f...
Metformin has been one of the most widely prescribed oral medications for type II diabetes for over ...
Metformin, a widely prescribed anti-diabetic drug, shows anticancer activity in various cancer types...
Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer...
Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin pr...
Metformin is one of the most widely prescribed antidiabetics for type 2 diabetes. A critical role of...
Breast Cancer (BC) is the leading cause of cancer death in women. One BC subtype is very aggressive ...
PURPOSE: Inflammatory infiltration plays important roles in both carcinogenesis and metastasis. We a...
Epidemiology studies have found that type 2 diabetics treated with metformin are at a lower risk for...
Accumulating evidence suggests that metformin, used as an antidiabetic drug, possesses anti-cancer p...
There is a great and growing interest in the anti-cancer effects of the diabetes drug metformin as e...
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs ta...
International audienceMetformin was reported to inhibit the proliferation of many cancer cells, incl...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...
Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%) reflect...