Purpose: The purpose of the paper was to estimate the interdependence between selected macroeconomic variables and non-performing loans in Ghana using a Bayesian Vector autoregressive approach. Design/methodology/approach: This paper used annual series from 2008-2017 which was interpolated into quarterly frequencies to estimate how macroeconomic shocks affects quality of loan portfolio using a Bayesian Vector Autoregressive approach. Our Bayesian VAR system satisfied the stability condition where the inverse root polynomial is within the unit root circle hence our VAR system was deemed stable. The model was estimated at levels with 1 lag as indicated by the AIC and the SBIC Findings: The findings were that shocks to gross domestic product ,...