Effects of Apium graveolens extract on serum calcium and oxalate in ethylene glycol- induced kidney injury in male Wistar rats

Celery (Apium graveolens) is a biennial plant, belonging to family Apiaceae. Various parts of celeryare used in hepatic and spleen disorders, brain disorders, body pain, and sleep disturbances. The present study was planned to investigate the effect of celery ethanolic extract on ethylene glycol induced kidney injury in male Wistar rats. Urolithiasis was induced in hyperoxaluric rat model by giving 0.75% ethylene glycol for 28 days. Animals were divided into 8 groups (n=6) including normal control, urolithiatic control (0.75% ethylene glycol in their drinking water), normal rats receiving celery extract at doses of 50, 100 and 200 mg/kg and urolithiatic rats receiving celery extract at doses of 50, 100 and 200 mg/kg intragastrically. At the end of the experiment (28 days), blood samples were collected by cardiac puncture and serum calcium and oxalate was analyzed. Statistical analysis was performed by one-way analysis of variance followed by Tukey post hoc test (p