The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium Valproate

Background: Migraine and other recurrent headaches are considered a major public health concern. Levetiracetam, a broad spectrum anti-epileptic have been used in migraine prophylaxis. Objectives: Assessment the efficacy of levetiracetam on migraine in comparison to sodium valproate. Materials and Methods: This randomized double blind clinical trial was performed on patients with migraine headache, diagnosed based on ICDH-version B criteria. One group received levetiracetam and the other group received valproate sodium. The number of migraine attacks per month, the mean duration of attacks and the intensity of pain (VAS) and disability due to headache (MIDAS) were assessed at first and after four weeks of treatment. Data were analyzed in SPSS 20 by Mann-Whitney-U and Chi-square tests. The significance level was set