CHANGES IN RETINAL NERVE FIBER LAYER ON OPTICAL COHERENCE TOMOGRAPHY AFTER PANRETINAL PHOTOCOAGULATION IN PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY

OBJECTIVE: To study changes in retinal nerve fiber layer (RNFL) measured on optical coherence tomography (OCT) after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR). METHODS: This quasi experimental study was conducted at Department of Ophthalmology, Lahore General Hospital, Lahore from 1-4-2017 to 30-3-2018. All patients (n=38) diagnosed with PDR requiring PRP were included. Patients having any coexisting ocular pathology hindering the OCT measurement were excluded. Pre-operatively, RNFL thickness in four quadrants and signal strength was measured on OCT and visual acuity (VA) on Snellen’s chart. Post-operatively, patients were followed-up after one-month and three-months and VA was measured and OCT performed. RESULTS: The mean age of patients was 60.66±5.51years with 23(60.5%)males. PRP was performed in right-eye of 22 patients. Pre-laser VA in 28 patients was 6/60. Pre-laser total RNFL was 84.32±4.78µm reduced to 83.74±4.61µm one-month and 81.89±4.40µm three-months post-laser (p<0.001). Pre-laser, superior RNFL thickness was 84.97±4.13µm, reduced to 84.39±3.95µm one-month and to 82.21±3.84µm at three-months post-laser (p 0.024). Pre-laser inferior RNFL thickness was 84.89±4.68µm, reduced to 84.00±4.44µm one-month and to 81.71±4.50µm three months post-laser (p=0.032). Pre-laser temporal RNFL thickness was 83.26±3.47µm, reduced to 82.34±3.44µm one-month and to 80.21±3.49µm three-months post-laser (p