Summary: Both innate and adaptive immune cells are involved in the pathogenesis of nonalcoholic steatohepatitis (NASH), but the crosstalk between innate and adaptive immunity is largely unknown. Here we show that compared with WT mice, OX40−/− mice exhibit decreased liver fat accumulation, lobular inflammation, and focal necrosis after feeding with diets that induce NASH. Mechanistically, OX40 deficiency suppresses Th1 and Th17 differentiation, and OX40 deficiency in T cells inhibits monocyte migration, antigen presentation, and M1 polarization. Soluble OX40 stimulation alone upregulates antigen presentation, chemokine receptor expression, and proinflammatory cytokine secretion by liver monocytes. Furthermore, plasma soluble OX40 levels are...
The nature of the chronic inflammatory component that drives the development of non-alcoholic steato...
Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and ...
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumu...
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proathe...
Background/Aims: Hepatic oxidative stress is a key feature of metabolic forms of steatohepatitis, bu...
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proathe...
Background/Aims: Hepatic oxidative stress is a key feature of metabolic forms of steatohepatitis, bu...
Category: Integrated Physiology - Liver: abstract no. 1655-PRESULTS: Nonalcoholic steatohepatitis (N...
International audienceObesity predisposes to an increased risk of nonalcoholic fatty liver disease (...
Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40-CD40 ligand ...
Nonalcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation combined with inf...
Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40- CD40 ligand...
Nonalcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation combined with inf...
Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and ...
BACKGROUND: Non-alcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation comb...
The nature of the chronic inflammatory component that drives the development of non-alcoholic steato...
Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and ...
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumu...
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proathe...
Background/Aims: Hepatic oxidative stress is a key feature of metabolic forms of steatohepatitis, bu...
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proathe...
Background/Aims: Hepatic oxidative stress is a key feature of metabolic forms of steatohepatitis, bu...
Category: Integrated Physiology - Liver: abstract no. 1655-PRESULTS: Nonalcoholic steatohepatitis (N...
International audienceObesity predisposes to an increased risk of nonalcoholic fatty liver disease (...
Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40-CD40 ligand ...
Nonalcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation combined with inf...
Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40- CD40 ligand...
Nonalcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation combined with inf...
Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and ...
BACKGROUND: Non-alcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation comb...
The nature of the chronic inflammatory component that drives the development of non-alcoholic steato...
Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and ...
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumu...