Abstract We generated a novel mouse strain expressing transgenic human interleukin-15 (IL-15) using the severe immunodeficient NOD/Shi-scid-IL-2Rγ null (NOG) mouse genetic background (NOG-IL-15 Tg). Human natural killer (NK) cells, purified from the peripheral blood (hu-PB-NK) of normal healthy donors, proliferated when transferred into NOG-IL-15 Tg mice. In addition, the cell number increased, and the hu-PB-NK cells persisted for 3 months without signs of xenogeneic graft versus host diseases (xGVHD). These in vivo-expanded hu-PB-NK cells maintained the original expression patterns of various surface antigens, including NK receptors and killer cell immunoglobulin-like receptor (KIR) molecules. They also contained significant amounts of gra...
Immune deficiency immediately following bone marrow transplantation (BMT) increases susceptibility t...
Item does not contain fulltextAdoptive transfer of allogeneic natural killer (NK) cells represents a...
International audienceThe ability of natural killer (NK) cells to kill tumor cells without antigen r...
Immunodeficient mice reconstituted with a human immune system represent a promising tool for transla...
Immunodeficient mice reconstituted with a human immune system represent a promising tool for transla...
Mice reconstituted with human immune systems are instrumental in the investigation of HIV-1 pathogen...
International audienceThe in vivo requirements for human natural killer (NK) cell development and di...
Studies of human NK cells and their role in tumor suppression have largely been restricted to in vit...
Natural killer (NK) cells play a significant role in reducing relapse in patients with hematological...
Allogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control c...
The immune system encompasses acquired and innate immunity that matures through interaction with mic...
<p>Adult NSG mice were injected <i>i.v.</i> with 5×10<sup>6</sup> UCB-NK cells with or without suppo...
Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment option for...
Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment option for...
Immune deficiency immediately following bone marrow transplantation (BMT) increases susceptibility t...
Item does not contain fulltextAdoptive transfer of allogeneic natural killer (NK) cells represents a...
International audienceThe ability of natural killer (NK) cells to kill tumor cells without antigen r...
Immunodeficient mice reconstituted with a human immune system represent a promising tool for transla...
Immunodeficient mice reconstituted with a human immune system represent a promising tool for transla...
Mice reconstituted with human immune systems are instrumental in the investigation of HIV-1 pathogen...
International audienceThe in vivo requirements for human natural killer (NK) cell development and di...
Studies of human NK cells and their role in tumor suppression have largely been restricted to in vit...
Natural killer (NK) cells play a significant role in reducing relapse in patients with hematological...
Allogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control c...
The immune system encompasses acquired and innate immunity that matures through interaction with mic...
<p>Adult NSG mice were injected <i>i.v.</i> with 5×10<sup>6</sup> UCB-NK cells with or without suppo...
Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment option for...
Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment option for...
Immune deficiency immediately following bone marrow transplantation (BMT) increases susceptibility t...
Item does not contain fulltextAdoptive transfer of allogeneic natural killer (NK) cells represents a...
International audienceThe ability of natural killer (NK) cells to kill tumor cells without antigen r...