Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on. The pathway is not only involved in the regulation of normal physiological processes, but also significant in the development of tumors, especially in hematologic malignancies. In recent years, with the further research of JAK/STAT signaling pathway, it has been found that the pathway also plays a key role in the development of solid tumors. Here we reviewed the research advances of JAK/STAT signaling pathway in lung cancer, especially the mechanisms of development, metastasis and drug resistance, ...
Over the past decade, there has been increasing biochemical evidence that the Janus kinase (JAK)/sig...
Summary: Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signalin...
SummaryPersistent activation of Stat3 is oncogenic and is prevalent in a wide variety of human cance...
Aberrant activation of signal transducer and activator of transcription (STAT) proteins is associate...
Aberrant activation of signal transducer and activator of transcription (STAT) proteins is associate...
Background: Janus kinase-signal transducer and activator of transcription (JAK-STAT) is a family of ...
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway was originall...
Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in signal tr...
Oncogenic KRAS has been difficult to target and currently there is no KRASbased targeted therapy ava...
Aberrant activation of intracellular signalling pathways confers malignant properties on cancer cell...
Department of Biochemistry, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau...
The Janus kinase (JAK) family are known to respond to extracellular cytokine stimuli and to phosphor...
Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates almost a...
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is now recogn...
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is now recogn...
Over the past decade, there has been increasing biochemical evidence that the Janus kinase (JAK)/sig...
Summary: Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signalin...
SummaryPersistent activation of Stat3 is oncogenic and is prevalent in a wide variety of human cance...
Aberrant activation of signal transducer and activator of transcription (STAT) proteins is associate...
Aberrant activation of signal transducer and activator of transcription (STAT) proteins is associate...
Background: Janus kinase-signal transducer and activator of transcription (JAK-STAT) is a family of ...
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway was originall...
Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in signal tr...
Oncogenic KRAS has been difficult to target and currently there is no KRASbased targeted therapy ava...
Aberrant activation of intracellular signalling pathways confers malignant properties on cancer cell...
Department of Biochemistry, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau...
The Janus kinase (JAK) family are known to respond to extracellular cytokine stimuli and to phosphor...
Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates almost a...
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is now recogn...
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is now recogn...
Over the past decade, there has been increasing biochemical evidence that the Janus kinase (JAK)/sig...
Summary: Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signalin...
SummaryPersistent activation of Stat3 is oncogenic and is prevalent in a wide variety of human cance...