The effect of diabetes on perioperative complications following spinal surgery: a meta-analysis

Wei Luo,1 Ru-xin Sun,2 Han Jiang,3 Xin-long Ma1 1Department of Orthopedics, Tianjin Hospital, Tianjin 300211, People’s Republic of China; 2Department of Gynaecology and Obstetrics, Tianjin Hongqiao Hospital, Tianjin 300131, People’s Republic of China; 3Department of Orthopedics, Tianjin Third Central Hospital, Tianjin 300170, People’s Republic of China Background: Degenerative spinal diseases and diabetes mellitus (DM) have increasingly become a social and economic burden. The effect of DM on spinal surgery complications reported by previous studies remains controversial. Methods: We searched MEDLINE, Cochrane CENTRAL, ScienceDirect, EMBASE, and Google Scholar to identify studies reporting the relationship between DM and spinal surgery complications. Two independent reviewers performed independent data abstraction. The I2 statistic was used to assess heterogeneity. A fixed-effects or random-effects model was used for the meta-analysis. Results: Twenty-four studies met the inclusion criteria. Surgical site infection and the incidence of deep venous thrombosis after spinal surgery were significantly higher in patients with than in patients without diabetes, and the length of hospital stay was significantly longer in patients with diabetes (P<0.05). No significant differences were observed in the risk of reoperation, blood loss, and operation time between patients with and those without diabetes (P>0.05). Conclusion: Patients with diabetes have a higher risk when undergoing spinal surgery than patients without diabetes. Diabetes increases the risks of postoperative mortality, surgical site infection, deep venous thrombosis, and a prolonged hospitalization time after spinal surgery. Keywords: diabetes mellitus, spine, surgery, complicatio