Clinical Features of CINin ChineseVery Elderly Patients Undergoing Coronary Angiography Procedure With Hydration Treatment: A Three-Center, Prospective Study

Summary: Background: To assess the morbidity and risk factors of contrast induced nephropathy (CIN) in Chinese very elderly patients. Methods: The very elderly patients whose age ≥75 year-old, from North Huashan Hospital, South Renji Hospital and Tongren Hospital, underwent coronary angiography or percutaneous coronary intervention, were included in this study. All of these patients were treated by hydration, those who developed contrast-induced nephropathy were divided into CIN group and the others were divided into non-CIN group. The baseline information was evaluated and serum creatinine was measured prior to the coronary angiography and 24 h, 48 h after procedure. The data was analyzed by the software SPSS17.0. Results: 163 very elderly patients were included in this study. The occurrence of CIN in very elderly patients was approximately 8.6%. In CIN group, serum creatinine concentration was statistical significance between prior data and 24 h/48 h after procedure data, but there's no statistically significant differences between 24 h data and 48 data after procedure. Multivariable analysis showed that patient's age (p value 0.026, OR 1.171, 95% CI 1.019–1.347), and complicated lesion (p value 0.025, OR 3.91, 95% CI 1.185–12.896) were correlation with CIN. Conclusion: The incidence of CIN with hydration treatment is similar to that of average patients. Very elderly patient with older age, higher dosage of contrast media and complicated lesion is vulnerable to develop CIN. Keywords: Contrast induced nephropathy, hydration treatment, morbidity, risk factors, very elderly patien