Interactions of multiple myeloma (MM) cells with endothelial cells (ECs) enhance angiogenesis and MM progression. Here, we investigated the role of Notch signaling in the cross talk between ECs and MM cells enabling angiogenesis. MMECs showed higher expression of Jagged1/2 ligands, of activated Notch1/2 receptors, and of Hes1/Hey1 Notch target genes than ECs from monoclonal gammopathy of undetermined significance patients, suggesting that homotypic activation of Notch pathway occurs in MM. MM cells co-cultured with MMECs triggered Notch activation in these cells through a cell-to-cell contact-dependent way via Jagged1/2, resulting in Hes1/Hey1 overexpression. The angiogenic effect of Notch pathway was analyzed through Notch1/2·siRNAs and th...
Multiple myeloma(MM) is an incurable hematological malignancy that develops in the bone marrow (BM) ...
Anti-angiogenesis agents and the identification of cancer stem-like cells (CSC) are opening new aven...
The formation of new blood vessels by angiogenesis requires the precise coordination of endothelial ...
Interactions of multiple myeloma (MM) cells with endothelial cells (ECs) enhance angiogenesis and MM...
Interactions of multiple myeloma (MM) cells with endothelial cells (ECs) enhance angiogenesis and MM...
Backgound: Multiple Myeloma (MM) is a hematopoietic malignant disease preceded by a Monoclonal Gammo...
Background: Multiple Myeloma (MM) is a hematopoietic malignancy characterized by proliferation of ma...
The progression of multiple myeloma (MM) is associated to a angiogenic switch. MM shows a dysregulat...
INTRODUCTION: Multiple myeloma (MM) is characterized by the accumulation of monoclonal plasma cells ...
Multiple myeloma(MM) is a still incurable cancer that strongly depends on interactions with bone mar...
Multiple myeloma(MM) is an incurable plasma cells malignancy. MM is characterized by aberrant activa...
Multiple myeloma (MM) is an incurable plasma cell malignancy arising primarily within the bone marro...
We investigated the role of Notch signaling in the vascular microenvironment, with particular attent...
Notch signaling is an evolutionarily conserved pathway and plays key roles in embryonic vascular dev...
Inhibition of Notch-mediated crosstalk between endothelial cells and plasmacells reduces angiogenesi...
Multiple myeloma(MM) is an incurable hematological malignancy that develops in the bone marrow (BM) ...
Anti-angiogenesis agents and the identification of cancer stem-like cells (CSC) are opening new aven...
The formation of new blood vessels by angiogenesis requires the precise coordination of endothelial ...
Interactions of multiple myeloma (MM) cells with endothelial cells (ECs) enhance angiogenesis and MM...
Interactions of multiple myeloma (MM) cells with endothelial cells (ECs) enhance angiogenesis and MM...
Backgound: Multiple Myeloma (MM) is a hematopoietic malignant disease preceded by a Monoclonal Gammo...
Background: Multiple Myeloma (MM) is a hematopoietic malignancy characterized by proliferation of ma...
The progression of multiple myeloma (MM) is associated to a angiogenic switch. MM shows a dysregulat...
INTRODUCTION: Multiple myeloma (MM) is characterized by the accumulation of monoclonal plasma cells ...
Multiple myeloma(MM) is a still incurable cancer that strongly depends on interactions with bone mar...
Multiple myeloma(MM) is an incurable plasma cells malignancy. MM is characterized by aberrant activa...
Multiple myeloma (MM) is an incurable plasma cell malignancy arising primarily within the bone marro...
We investigated the role of Notch signaling in the vascular microenvironment, with particular attent...
Notch signaling is an evolutionarily conserved pathway and plays key roles in embryonic vascular dev...
Inhibition of Notch-mediated crosstalk between endothelial cells and plasmacells reduces angiogenesi...
Multiple myeloma(MM) is an incurable hematological malignancy that develops in the bone marrow (BM) ...
Anti-angiogenesis agents and the identification of cancer stem-like cells (CSC) are opening new aven...
The formation of new blood vessels by angiogenesis requires the precise coordination of endothelial ...