A primary mechanism for activation of innate immunity is recognition of damage or pathogen associated molecular patterns by pattern recognition receptors (PRRs). Nucleic acid is a damage associated molecular pattern molecule that when internalized into a monocyte and recognized by intracellular nucleic acid sensing toll like receptors will cause production of type 1 interferon. The process by which DNA or RNA is delivered into the cytosol of monocytes in systemic lupus erythematosus remains incompletely understood, and therapeutic approaches to prevent DNA-mediated monocyte activation are needed. We identified two mechanisms for internalization of DNA by monocytes. IgG-bound DNA was internalized by interacting with Fc gamma receptor IIa, wh...
textabstractBackground: Childhood-onset systemic lupus erythematosus (cSLE) is an incurable multi-sy...
Background: Monocytes -key regulators of the innate immune response- are actively involved in the pa...
Activation of the innate immune system by toll-like receptors (TLR) provides an early response to pa...
A primary mechanism for activation of innate immunity is recognition of damage or pathogen associate...
A primary mechanism for activation of innate immunity is recognition of damage or pathogen associate...
A hallmark of systemic lupus erythematosus (SLE), and several related autoimmune diseases, is the pr...
Anti-double stranded DNA antibodies (anti-dsDNA) are a hallmark of SLE but their role in disease pat...
Anti-DNA autoantibodies are a hallmark of systemic lupus erythematosus (SLE). A subset of anti-DNA I...
Patients with systemic lupus erythematosus (SLE) have an activated type I interferon (IFN) system wi...
Anti-DNA antibodies are hallmark autoantibodies produced in systemic lupus erythematosus (SLE), but ...
Summary: Interferon α (IFNα) is a prompt and efficient orchestrator of host defense against nucleic ...
Systemic lupus erythematosus (SLE) is an auto-immune disorder in which the production of autoantibod...
Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulat...
Systemic autoimmune disease is characterized by loss of immunologic tolerance to a restricted set of...
Thesis (Ph.D.)--University of Washington, 2013Several lines of evidence implicate type I interferons...
textabstractBackground: Childhood-onset systemic lupus erythematosus (cSLE) is an incurable multi-sy...
Background: Monocytes -key regulators of the innate immune response- are actively involved in the pa...
Activation of the innate immune system by toll-like receptors (TLR) provides an early response to pa...
A primary mechanism for activation of innate immunity is recognition of damage or pathogen associate...
A primary mechanism for activation of innate immunity is recognition of damage or pathogen associate...
A hallmark of systemic lupus erythematosus (SLE), and several related autoimmune diseases, is the pr...
Anti-double stranded DNA antibodies (anti-dsDNA) are a hallmark of SLE but their role in disease pat...
Anti-DNA autoantibodies are a hallmark of systemic lupus erythematosus (SLE). A subset of anti-DNA I...
Patients with systemic lupus erythematosus (SLE) have an activated type I interferon (IFN) system wi...
Anti-DNA antibodies are hallmark autoantibodies produced in systemic lupus erythematosus (SLE), but ...
Summary: Interferon α (IFNα) is a prompt and efficient orchestrator of host defense against nucleic ...
Systemic lupus erythematosus (SLE) is an auto-immune disorder in which the production of autoantibod...
Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulat...
Systemic autoimmune disease is characterized by loss of immunologic tolerance to a restricted set of...
Thesis (Ph.D.)--University of Washington, 2013Several lines of evidence implicate type I interferons...
textabstractBackground: Childhood-onset systemic lupus erythematosus (cSLE) is an incurable multi-sy...
Background: Monocytes -key regulators of the innate immune response- are actively involved in the pa...
Activation of the innate immune system by toll-like receptors (TLR) provides an early response to pa...